Sarcoidosis – an unusual multisystemic disease

Abstract

Sarcoidosis is a chronic multisystemic disease of unknown etiology, characterized by the formation of non-caseous granulomas, most commonly with lung, intrathoracic lymph node, skin and ocular involvement. We present the case of a 69-year-old male with hyperthyroidism due to a toxic nodule who underwent a thyroidectomy but kept losing weight. Afterwards he developed photopsias, hepatosplenomegaly and pancytopenia. Exams revealed non-caseous granulomatous involvement of thyroid, eye, liver and bone marrow. Corticosteroid therapy was initiated with overall improvement. This case illustrates an infrequent case of sarcoidosis with exclusive extra-thoracic disease, highlighting the rare bone marrow and thyroid involvement causing an unspecific presentation.